Since running anything in wine is pretty much like running it in an isolated virtual machine, you don't have to worry about it. It cannot delete your disk, nor cause any damage. If it breaks your "Office 2010" prefix, you just delete the prefix directory and reinstall it again as if nothing happened. That is the beauty of running stuff under wine - I ran tons of suspicious stuff and not once had it caused any problems. You don't have to run an antivirus in a wine prefix 
Just don't save your files in the wine prefix Documents folder (the one that Windows would use), but use the Linux Documents folder. Also regarding word or excel macros, they are harmless under wine. Use the whole wine prefix as 1 application containing only Office and nothing else, no documents.
Just don't save your files in the wine prefix Documents folder (the one that Windows would use), but use the Linux Documents folder. Also regarding word or excel macros, they are harmless under wine. Use the whole wine prefix as 1 application containing only Office and nothing else, no documents.