Hi kdemeoz,
All those kernel updates as you call them are of the same kernel version (4.4), so that wouldn't solve anything - those are in most cases just security updates. On the other side, kernel from 16.04.2 is part of the Hardware Enablement Stack, which aims to resolve HW issues and bring new versions of drivers etc. So you cannot compare them.
As for the multi-keyboard/mouse setup, well it is quite unusual, but of course it should work. Since the freezes continue, it's obvious it has nothing to do with the graphics driver. Maybe just try to pull out and plug in the keyboards and mice when the freeze occurs - maybe they are "reset" and the system re-configures them. I suppose this doesn't happen with your laptop, just tower.
From what I can read by some googling, it seems that there can be various problems with various combinations of input devices, when used in such a multiple-device setup. What I would maybe recommend (though this would require spending some money) is to buy a Logitec wireless keyboard and mouse (or multiple number of them) and use them via the Logitech Unifying dongle. You can pair up to 6 devices per 1 dongle and it all goes in via 1 USB port. Don't really know if it would solve you problems, but it's just a thought. Anyway, I'm pretty much 99% sure that the problems you have come from those multiple devices.
All those kernel updates as you call them are of the same kernel version (4.4), so that wouldn't solve anything - those are in most cases just security updates. On the other side, kernel from 16.04.2 is part of the Hardware Enablement Stack, which aims to resolve HW issues and bring new versions of drivers etc. So you cannot compare them.
As for the multi-keyboard/mouse setup, well it is quite unusual, but of course it should work. Since the freezes continue, it's obvious it has nothing to do with the graphics driver. Maybe just try to pull out and plug in the keyboards and mice when the freeze occurs - maybe they are "reset" and the system re-configures them. I suppose this doesn't happen with your laptop, just tower.
From what I can read by some googling, it seems that there can be various problems with various combinations of input devices, when used in such a multiple-device setup. What I would maybe recommend (though this would require spending some money) is to buy a Logitec wireless keyboard and mouse (or multiple number of them) and use them via the Logitech Unifying dongle. You can pair up to 6 devices per 1 dongle and it all goes in via 1 USB port. Don't really know if it would solve you problems, but it's just a thought. Anyway, I'm pretty much 99% sure that the problems you have come from those multiple devices.